long-term complications

Why 6 Breaths/Minute Improves Heart Health & Quality of Life in Diabetes

Slow breathing is a highly effective yet overlooked therapy for diabetes.

 

It profoundly changed my life with diabetes, leading me to spend the past 5 years trying to understand it and share it with others.

 

I’ve found that it’s not going to fix everything (of course).  It may not even impact your blood sugars.  But, without question, two things it will do are improve your heart health and your quality of life.

 

And it’s available anytime, anywhere (no pre-authorization required). 

 

I think it’s a no-brainer for better health, and I hope this article inspires you to give it a try.

 

 

What is Slow Breathing? (and why was 6 breaths/minute in the title?)

 

Slow breathing is broadly defined as breathing at a rate of less than 10 breaths per minute.  More specifically, it usually refers to breathing at a rate of about 4.5 to 7 breaths per minute.

 

And even more specifically, almost every study on slow breathing and diabetes has used 6 breaths per minute.  And they’ve found some pretty remarkable things.

 

But before we get to that, let’s take a quick look at the breath-heart connection.

 

 

Understanding the Breath-Heart Connection: Respiratory Sinus Arrhythmia and Heart Rate Variability

 

When we inhale, our heart rate increases.  When we exhale, it decreases (if you’d like more details, here’s a blog I wrote for ResBiotic that explains it fully).  This is known as respiratory sinus arrhythmia (RSA).

 

RSA is one of the underlying principles of heart rate variability (HRV).  Generally speaking, HRV is the beat-to-beat time variability of heart rate.  Research shows that higher HRV indicates a more balanced nervous system and better cardiovascular health.  For these reasons, higher HRV is associated with a better quality of life.

 

And it turns out that people with diabetes typically have worse HRV than non-diabetics.  (A negative side-effect of researching diabetes is that it reminds me of everything it adversely affects.  However, it’s also encouraging to find simple tools like breathing that can help (not fix) some of the problems).

 

 

HRV is Reduced in Diabetes

 

A 2018 meta-analysis found that patients with type-2 diabetes had significantly lower HRV than those without it.  Diabetics with chronic complications have even lower HRV

 

The lower HRV observed in people with diabetes is likely related to many negative aspects of the disease, such as chronic stress, inflammation, and increased oxidative stress. 

 

Perhaps unsurprisingly, low HRV is associated with adverse outcomes in diabetes.  For example, people with diabetes and low HRV are at increased risk of coronary heart disease.  Moreover, low HRV is an early marker of cardiac autonomic neuropathy, which can lead to heart disease, the number one cause of mortality in people with diabetes.

 

Sounds depressing, right?

 

 

Enter the Heart-Boosting Power of Slow Breathing

When we breathe slowly at around 6 breaths per minute, we synchronize signals coming from our cardiovascular, respiratory, and autonomic nervous systems. 

When we breathe slowly at around 6 breaths per minute, we synchronize signals coming from our cardiovascular, respiratory, and autonomic nervous systems. 

 

To get a little more technical, we have baroreceptors monitoring blood pressure. They sense the changes in heart rate that accompany each breath.  Then, they send their own signals to the heart. 

 

For example, as blood pressure rises, they tell the heart to slow down.  And as blood pressure falls, they tell the heart to speed up.

 

Here’s the issue: there’s about a 5-second lag for signals.  Thus, they end up getting mingled together with the signals from the breath.  One may be trying to increase heart rate while the other is trying to slow it down.

 

But when we breathe at about 6 breaths per minute, we synchronize these messages.  (To breathe at 6 breaths per minute, we need about a 5-second inhale and 5-second exhale (or 4/6 also works). This matches the time lag from the baroreceptors.)

 

When the signals get synchronized, great things happen.  Each breath amplifies heart rate oscillations, leading to greater HRV.  This also balances the nervous system, making us calm and relaxed.  If we do this regularly, it can significantly improve our quality of life.

 

Let’s break these down into a little more detail and look at 4 positive outcomes we get from slow breathing.

 

 

The 4 Key Benefits of Heart-Breath Synchronization for Diabetes

 

1. Improved Heart Rate Variability

 

This is the most potent effect.  As mentioned, when we breathe slowly, we amplify the heart rate oscillations occurring with each breath.  This increases HRV, a critical problem in diabetes.

 

One study published in Nature found that just 2 minutes of slow breathing at 6 breaths/min could bring the HRV of type-1 diabetics to levels of non-diabetic controls.  (Side note: this was the paper that convinced me to start sharing this information.  Nature is one of the most prestigious journals in the world.  If they’re talking about slow breathing and diabetes, I realized my results weren’t so crazy after all.)

 

A long-term study of people with type 2 diabetes and ischemic heart disease found that one year of slow diaphragmatic breathing significantly increased HRV, and this wasn’t even at precisely 6 breaths per minute. Just slowing down the breath was enough to boost HRV.

 

And better HRV means better cardiovascular health and a longer life.

 

It also means more resiliency to diabetic stressors, but I’ll save that for another blog post.

And better HRV means better cardiovascular health and a longer life.

 

2. Efficiency and Blood Flow

 

When bodily messages come into harmony, it creates efficiency.  Efficiency means your body doesn’t have to work as hard to complete its normal processes.

 

This efficiency also improves blood flow, a fundamental problem in diabetes.  For example, the same 2-minute study mentioned above found that slow breathing also improved arterial function.  Better arteries, more blood flow, and less chance of complications.

 

 

3. Reduced Blood Pressure

 

Slow breathing has consistently been shown to lower blood pressure.  A 2019 meta-analysis found an average systolic blood pressure reduction of about 5 points from slow breathing for about 20 minutes daily.

 

The blood pressure-reducing effects of slow breathing have also been shown in diabetes.  In a study of 65 type-2 diabetics with hypertension, slow breathing significantly reduced systolic and diastolic blood pressure.

 

These results are significant because Johns Hopkins Medical Center reports that people with diabetes are twice as likely to develop hypertension.  It’s also estimated that anywhere from 40 to 80% of diabetics have hypertension.  Moreover, a person with diabetes and hypertension is four times more likely to develop heart disease.  For these reasons, preventing and treating hypertension is a chief concern in people with diabetes.

 

Slow breathing provides one complementary therapy for doing just that.

 

 

4. Less Stress & Anxiety

 

And lastly, we can’t discuss heart problems without discussing stress.  We know when we’re stressed, we have chronic activation of the sympathetic (fight-or-flight) nervous system.  This raises heart rate and blood pressure, adding extra strain on our hearts.

 

Fortunately, slow breathing is one of the fastest and most effective ways to alleviate stress. You’ve probably been told at some point in your life to “just take a deep breath.”  It turns out there’s some solid science for this statement.

 

Slowing down the breath, especially with a longer exhalation, increases activity in the parasympathetic nervous system (rest-and-digest), reducing stress and increasing relaxation. Slow breathing also reduces activity in the amygdala (often referred to as the “fear center”), which also helps reduce stress.

 

 

Slow Breathing is a Superpower for Your Heart

 

To recap, slow breathing at about 6 breaths per minute is excellent for our hearts, especially if you have diabetes.

 

It harmonizes messages being sent from the cardiovascular and autonomic nervous systems.  This leads to a ton of benefits, but here are 4 critical ones for diabetic heart health:

 

  • Improved heart rate variability

  • Increased efficiency and blood flow

  • Lower blood pressure

  • Less stress and anxiety

 

For these reasons, the paper published in Nature concluded:

Slow breathing could be a simple beneficial intervention in diabetes.
— Nature Scientific Reports

 

Simple and beneficial, indeed.

 

 

Start Improving Your Heart Health Today

 

I hope this article motivates you to start a slow breathing practice.

But, if you’d like some more help, you can check out the Breathing for Diabetes Online Course, which covers everything you need to get started.

I hope you’ll check it out, and if you have any questions about slow breathing in general, please email me at nick@thebreathingdiabetic.  I always respond within 5 days (but usually ~2).


Breathing for Diabetes Online workshop

This may be your key to a healthy, more fulfilling life with diabetes.


 


Become A World-Class Breather

 

Greetings,

Here are four thoughts, one quote, and one answer to start off February. Enjoy!

 
 

 
 

4 THOUGHTS

1. Become a World-Class Breather

"World-class performers are less about complexity and more about optimizing simplicity…It’s about the fundamentals. But small, daily improvements on the fundamentals every day done with ridiculous consistency creates insane revolutions over time."

- Robin Sharma, Optimize Interview

Becoming a world-class breather is actually quite simple: reduce the complexity, optimize the simplicity.

Of course, you can still utilize a variety of advanced techniques. Kobe Bryant didn’t only practice shooting free throws, and Tom Brady doesn’t only practice taking snaps. But it all starts with optimizing the fundamentals.

The best way to do that? Nose, belly, quiet, slow, repeat. Let those benefits compound into "insane revolutions over time."

P.S. Don’t forget James Clear’s advice: We have to start before we can optimize.

P.P.S. I condensed the quote, but I’ve never heard so many buzzwords stringed together so eloquently and with so much conviction : ) Enjoy listening.

2. What Optimal Breathing Can Do for Diabetes 

Although it’s not a panacea, improving our breathing might be the simplest thing we can do for our overall health. And for diabetes, in particular, optimal breathing has several direct and indirect benefits that are especially useful.

For example, it can improve cardio-autonomic function, reduce stress and anxiety (see next thought), improve blood flow, and improve sleep. These benefits can lead to better insulin sensitivity, more stable blood sugars, and less risk of long-term complications. Not bad for something as simple as breathing.

3. Harvard Business Review: Why Breathing Is So Effective at Reducing Stress

"So what makes breathing so effective? It’s very difficult to talk your way out of strong emotions like stress, anxiety, or anger…But with breathing techniques, it is possible to gain some mastery over your mind."

- Harvard Business Review,
Research: Why Breathing Is So Effective at Reducing Stress

So much goodness in this quick article. It’s a nice complement to last week’s thought on using breathing instead of thinking, and much more. Enjoy!

4. A Breathing Competition?

Compete: from Latin competere,

in its late sense 'strive or contend for (something)'

from com = 'together' + petere = 'aim at, seek'

- Apple Dictionary

So to "compete" literally means to strive for something together. In that case, we can consider this newsletter to be a breathing competition, with all of us striving to become world-class breathers together.

I hope you enjoy this competition as much as I do.

This thought was inspired by this Optimize +1

 
 

 
 

1 QUOTE

"The pattern of your breathing affects the pattern of your performance. When you are under stress, deep breathing helps bring your mind and body back into the present."

– Gary Mack, Mind Gym

 
 

 
 

1 ANSWER

Answer: This is the longest recorded breath-hold that didn’t use pure oxygen inhalation.

(Cue the Jeopardy! music.)

Question: What is 11 min 35 sec?


 
 

Breathing Restores Autonomic Control in Type-2 Diabetics with Complications

 

Quit worrying about your health. It’ll go away.” - Robert Orben

 
 

As people with diabetes (type 1 or 2), we know our bodies are under extra stress. This is due to things like fluctuating blood sugars and chronic inflammation. These factors can gradually accumulate into nerve damage and a variety of other long-term complications.  

However, we have recently learned that some “long-term complications” are functional and reversible (at least in their early stages). One way to reverse them is slow breathing.

Slow breathing treats the root cause of many complications, tissue hypoxia, which then restores autonomic functioning. This has been proven in several studies involving people with type-1 diabetes. However, most participants had not yet developed severe complications.

Putting Slow Breathing to the Test

It seems reasonable to assume that slow breathing would have the same effects in type 2s. But, what if these people with type-2 diabetes have chronic kidney disease? With a severe complication such as this, could slow breathing still have the same benefits?

 
 

 
 

Trained breathing-induced oxygenation acutely reverses cardiovascular autonomic dysfunction in patients with type 2 diabetes and renal disease

Published in Acta Diabetologica, 2016

Click Here to Read the Full Summary

 
 

 
 

The Study Group and Breathing Protocol

This study had 26 type-2 diabetic patients, 12 of which had diabetic kidney disease, and 24 non-diabetic controls. The protocol was simple: They had the participants lay down and breathe normally for five minutes, followed by two minutes of slow breathing at 6 breaths per minute.

The primary outcome was a change in baroreflex sensitivity (BRS). BRS measures your body’s ability to quickly adjust blood pressure to meet the current demands of your situation. It is thought to be an overall measurement of autonomic and cardiovascular control. In general, diabetics have lower BRS scores than non-diabetics.


Slow Breathing Improves Autonomic Function in Diabetics With Kidney Disease

At baseline, the type-2 diabetics had a lower resting oxygen saturation and lower BRS. When they switched to breathing at 6 breaths per minute, their oxygen saturation and BRS both increased significantly. Their blood pressure also reduced.

Perhaps most importantly, these same changes were observed in the diabetics with kidney disease. Both sets of diabetics (kidney disease and no complications) showed similar increases in BRS and oxygen saturation.  This indicates that, even in diabetics with severe complications, slow breathing can acutely reverse autonomic dysfunction.


Getting Back to Tissue Hypoxia

The authors suggest that these improvements in autonomic function were due to increases in tissue oxygenation. Similar to the study we featured on type-1 diabetes, they indicate that by increasing tissue oxygen levels, sympathetic activity is reduced, and autonomic balance is restored.


A New Model of Diabetic Complications

These results again indicate that autonomic dysfunction is not an expression of nerve damage. Instead, it is a reversible phenomenon that might actually be the precursor to nerve damage.  This paradigm-shifting view opens the door to new opportunities for treating autonomic dysfunction in diabetics.


In good breath,

Nick

P.S. A Zoom Meeting I would Look Forward To.


P.P.S. James Nestor’s new book, Breath: The New Science of a Lost Art, comes out tomorrow. I don’t know James, but from the podcast interviews I’ve heard so far, this sounds like a must-read if you’re into all this “breathing” stuff :)

And if you really want to geek out, James and Patrick McKeown got together for an hour long conversation on all things breathing. Watch/Listen Here.


 
 

Lack of Oxygen Might be the Root Cause of Diabetic Complications

 
 

Since we cannot know all that there is to be known about anything, we ought to know a little about everything.- Blaise Pascal

 
 

 
 

People with diabetes are at an increased risk of cardiovascular and autonomic problems. Diabetics also display altered respiratory control, for example, showing depressed (or enhanced) chemoreflexes.

However, previous studies have never examined these two aspects in an integrated fashion.

Integration Over Isolation

The problem with separately studying these systems is that the results might not be independent. For example, if a study shows that diabetics have decreased respiratory control, it might conclude that this is from diabetic nerve damage.

Likewise, if a study shows that cardiovascular function is depressed, it might also conclude that this is due to diabetic nerve damage.

However, if we study them together, we might find that there is a reciprocal relationship. Maybe the respiratory problems are causing cardiovascular issues? Perhaps it’s the other way around?

This study takes that approach and has some pretty remarkable conclusions.

Integrated cardiovascular/respiratory control in type 1 diabetes evidences functional imbalance: Possible role of hypoxia

(Click Here to Read Full SummaryI don’t say this often, but please read this one if you have diabetes)

Published in the International Journal of Cardiology, 2017.

In forty-six type-1 diabetics and 103 age-matched controls, they measured baroreflex sensitivity (BRS) as a marker of cardiovascular function and chemoreflexes as a marker of respiratory control.

Chemoreflexes estimate how sensitive you are to increasing CO2 (hypercapnic chemoreflex) and decreasing O2 (hypoxic chemoreflex).

The Hypothesis: If BRS and chemoreflexes are reduced, this would suggest diabetic nerve damage. However, if some are reduced while others are elevated, this reciprocal relationship might be showing autonomic dysfunction instead of diabetic nerve damage.

This is such an important distinction. “Damage” implies that the damage is done. “Dysfunction” implies that we could make it functional again.

Diabetics Have Worsened Cardiovascular and Respiratory Control

The results showed that subjects with diabetes had a lower BRS than the controls. They also had a suppressed hypoxic chemoreflex. However, they had an elevated hypercapnic chemoreflex. (Remember their hypothesis: if it was nerve damage, both of these chemoreflexes would be reduced.)

Interestingly, the diabetics also showed a lower oxygen saturation. And, they also had relatively high HbA1c’s (an average of 8.19%). A high HbA1c will decrease oxygen delivery to the tissues and cells.

Tissue Hypoxia is at the Root of Diabetic Complications

The reduced oxygen saturation and high HbA1c suggest a resting state of tissue hypoxia in diabetes. Over time, we become “numb” to this, which explains the decreased hypoxic chemoreflex.

The body compensates with an up-regulated hypercapnic chemoreflex, which leads to chronic activation of the sympathetic nervous system (fight or flight).  Chronic sympathetic activation then suppresses our cardiovascular control.

It’s a vicious cycle with negative long-term implications:


 
 
Root_of_Complications_Cycle.png
 
 

Dysfunction, not Damage: A Silver Lining

“We show in the present study that what is normally called ‘autonomic neuropathy’ could be in many cases a functional condition of sympathetic activation, driven by many factors, one of which seems to be resting hypoxia.”


This is all actually good news.  Their results suggest that diabetic autonomic imbalance is mainly functional and not related to nerve damage.  In fact, the authors suggest that this imbalance likely leads to nerve damage, rather than being the result of it. Therefore, therapies targeting cardio-respiratory control could help reverse/prevent diabetic complications if caught early enough.

Break Out Your Slow Breathing Hammer

What are these therapies? One is slow breathing. Slow breathing will immediately improve cardiovascular and respiratory reflexes. It will also enhance oxygenation (when breathing through the nose).

I hate sounding like all I have is a “slow breathing hammer,” but it is just too important not to stress over and over again.

Here’s to taking the first step toward protecting our long-term health as diabetics.

In good breath,
Nick


P.S. A great podcast was recently released with James Nestor, author of the soon-to-be-released book: “Breath - The New Science of a Lost Art”. (The book looks terrific, so I pre-ordered my copy about a week ago.)

You can basically learn everything you’ll ever need to know about breathing in this quick 35-minute interview. I loved it.

Listen to the podcast here.

 
 

Are Long-Term Diabetic Complications Reversible?

Fred_Rogers_Helpers.png
 

As a person with type-1 diabetes, long-term complications are like the boogeyman. I hide under the covers, turn off the lights, and they can’t get me. I am healthy, after all. Right?

But the truth is, diabetic complications are more common than I would like to admit. There are, however, two pieces of good news.  

There is Always Good News

First, a popular study showed that for every 1% reduction in HbA1c, there was a significant reduction in the risk of many diabetic complications.  

For example, in type-2 diabetics, a 1% drop in HbA1c was associated with a 14% drop in heart attacks. Because we know that slow breathing can help reduce HbA1c, this is more motivation to be consistent with our breathing practice (and exercising, eating healthy, and sleeping more).

Second, the study I’m sharing this week found that some diabetic complications are reversible by slow deep breathing:


Deep breathing improves blunted baroreflex sensitivity even after 30 years of type 1 diabetes

(Click Here to Read Full Summary)

Journal: Diabetologia, Volume 54, Article number: 1862 (2011)

Baroreflex sensitivity (BRS) measures your heart’s ability to adjust your blood pressure in response to changing conditions. It’s also an early indicator of autonomic dysfunction. People with diabetes typically have reduced BRS, even before other complications show up.

This study found that slow breathing at six breaths/min restored BRS to normal levels, even in long-duration type-1 diabetics (>30 years). These results indicate that reduced BRS in diabetics is partially functional and hence partially reversible.

How did slow breathing do this? The authors showed that it increased heart rate variability and parasympathetic tone, leading to improved cardiovascular and autonomic functioning.


More Benefits of Slow Breathing for Diabetics

While getting this post ready, I was considering all of the research showing the benefits of slow breathing for diabetes. This inspired me to create this little graphic, which I think sums it up succinctly.

 
 
Benefits_of_Slow_Breathing.png
 
 


The earlier we address the adverse effects of diabetes, the better our chances are of avoiding complications.

In good breath,
Nick

P.S. That is trust.

P.P.S. My stats for this week:

Average BOLT Score: 30 sec (Min: 26 sec, Max: 36 sec)
Average CO2 Tolerance: 64 sec (Min: 54 sec, Max: 82 sec)
Average Blood Sugar: 102 mg/dL (Min: 47 mg/dL, Max: 230 mg/dL)